Safe Prescribing: Navigating CYP3A and Polypharmacy

Developed in collaboration with the Royal College of Pharmacy, this course is for prescribing professionals across primary and secondary care managing patients with complex medication regimens.

Ideal for pharmacists, GPs, and other prescribers looking to strengthen their ability to identify and manage clinically significant drug interactions, including those involving CYP3A.
Write your awesome label here.

Developed by Leading Clinical Experts 

Professor Lauren Walker
Professor of Clinical Pharmacology & Therapeutics
Amira Shaikh

Academic Pharmacist
Royal College of Pharmacy
Professional leadership body for pharmacists and pharmaceutical scientists
Developed by EL Healthcare Education in collaboration with the Royal Pharmaceutical Society, clinical experts, frontline practitioners and experts by experience. Financial support was provided as a Medical Education Grant from Pfizer International LLC. Pfizer have provided only financial support and have no input into the content provided.

Learning Objectives

  • Define polypharmacy and describe its impact on patient safety and medicines optimisation
  • Explain the function and clinical relevance of the CYP3A enzyme system
  • Recognise high-risk CYP3A-mediated drug interactions in clinical practiceAssess the potential clinical consequences of these interactions
  • Apply appropriate strategies to manage interactions safely
  • Describe the role of emerging approaches, including pharmacogenomics and AI, in supporting prescribing decisions

Why should I take this course?

Polypharmacy is becoming an everyday reality in clinical practice - bringing increased complexity and a higher risk of adverse drug reactions and drug–drug interactions. CYP3A-mediated interactions, in particular, affect the metabolism of many commonly prescribed medicines and are a frequent source of preventable harm.

This course is designed to help you navigate that complexity with confidence. You’ll build practical skills to identify, assess and manage clinically significant interactions, using realistic case-based scenarios that reflect the challenges you face in practice.

By the end of the module, you’ll feel more confident making prescribing decisions in patients with complex medication regimens—supporting safer, more effective care across both primary and secondary settings.

Who is this course for?

This course is designed for prescribing professionals working across primary and secondary care who are managing patients with complex medication regimens.

It is particularly relevant for:

  • Independent and supplementary prescribers
  • Pharmacists and pharmacy-based prescribers
  • GPs and other primary care clinicians
  • Hospital-based prescribers managing acute and long-term conditions

If you regularly encounter polypharmacy in your practice and want to strengthen your ability to identify and manage clinically significant drug interactions—especially those involving CYP3A—this course will support you to make safer, more confident prescribing decisions.

Your Learning Journey 

Go mobile

This course is available for free on our App

Get the app to access this course anytime, anywhere — and make CPD fit around your busy schedule.
Write your awesome label here.
Created with